… In this study, we examined the cytotoxicity and antiproliferative potential of seven novel
octahydropyrazin[2,1-a:5,4-a′]diisoquinoline derivatives (1–7) (Figure 1) in estrogen receptor–…

… The mitochondrial pathway can be activated by a diverse range of stimuli, including reactive
oxygen species, radiation and chemotherapeutic agents. Either caspase 8 or caspase 9 can …

… chemotherapeutic agent in gastric cancer treatment. The effect of the tested compounds (1, …
Our results suggest that novel diisoquinoline derivatives might be promising agents in gastric …

… Our studies suggest that cytotoxic activity of chemotherapeutic agents (OM-90, etoposide)
is enhanced by Nigella sativa oil or extract. Our results contradict with the study performed by …

… that the new diisoquinoline derivatives could modulate both … novel octahydropyrazin[2,1-a:5,4-a′]diisoquinoline
derivative (OM… Anticancer agents can be designed to target specific cell …

… two or three chemotherapeutic agents paired with biologics such as anti-VEGF agents or
anti-EGFR drugs… and a novel octahydropyrazino[2,1-a:5,4-a′]diisoquinoline derivative (OM-86II…

… Rabdosia rubescens and the whole plant was used as antibacterial and antitumor agents.
At this point, the biological properties of lasiokaurin and its derivatives needed to be revealed. …

… with the novel diisoquinoline derivative caused a decrease in … and 48 h of incubation,
respectively (Figure 4A,B). Taking into … that the combination of the chemotherapeutic agent with …

… novel approaches and new chemotherapeutic agents. Other … new biologically active molecules,
including anticancer activity… range of biological activities. Many mono and condensed 1,…

… Among the derivatives 2–12, 2 and 10 were weaker than parent compound 1, and the
others showed similar or better activity. As for 2–5 with R of aliphatic substituents, 4 was the …